Over the last decades, methicillin resistant Staphylococcus aureus (MRSA) had caused major problems in the hospitals throughout the world. Cajanus cajan, Kigelia africana, Plumbago zeylanica are medicinal plants commonly prescribe by traditional medical practitioner in Nigeria for treatment of infectious diseases, they were tested in vitro for their anti-MRSA properties against five clinical isolate of MRSA. The bacterial cultures used were strains isolated from patients. \nFresh plant materials were collected and air dried; methanolic extracts of the powdered plants samples were obtained by standard methods. Diameter zone of inhibition was used as a measure of the anti-MRSA properties using Gentamicin and Ofloxacin as reference standard in Agar diffusion assay.\nThe result revealed that the crude extracts of the leaf of Cajanus cajan and the root of Plumbago zeylanica were effective against MRSA with MIC as low 3.98 mg/ml and 1.58mg/ml respectively while the methanolic extract of the bark of Kigelia africana showed no significant activity against MRSA.\nThe result of this study offers a scientific basis for the use of the extracts of Cajanus cajan and Plumbago zeylanica against MRSA associated diseases
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